(S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester
CAS No.:120286-23-9
Molecular Formula:C₂₀H₃₂NO₇P
Molecular Weight:429.45
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester

Chemical Property:

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Technology Process of (S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester

There total 8 articles about (S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 120286-20-6,120286-21-7
(S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-4-(imidazole-1-carbothioyloxy)-butyric acid tert-butyl ester

: 120286-23-9
(S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester

Guidance literature:: With tri-n-butyl-tin hydride; In benzene; for 1.5h; Heating;
DOI:10.1055/s-1988-27707

Reference yield:

: 3160-47-2
N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester

: 120286-23-9
(S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / H₂SO₄ / CH₂Cl₂ / 48 h / Ambient temperature

2: 92 percent / 2M aq. NaOH / methanol / 3 h / Ambient temperature

3: 1.) N-methylmorpholine, ethyl carbonochloridate, 2.) NaBH₄ / 1.) THF, -10 deg C, 1 min; -5 deg C, 15 min, 2.) THF, water, room temp., 3.5 h

4: 60 percent / CrO₃, pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 99 percent / benzene / 1 h / Heating

6: 95 percent / 95percent aq. AcOH / 24 h / Ambient temperature

7: 95 percent / 1,2-dichloro-ethane / 3 h / 70 °C

8: 99 percent / n-Bu₃SnH / benzene / 1.5 h / Heating

With 4-methyl-morpholine; pyridine; chromium(VI) oxide; sodium hydroxide; sodium tetrahydroborate; sulfuric acid; tri-n-butyl-tin hydride; chloroformic acid ethyl ester; acetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; benzene;
DOI:10.1055/s-1988-27707

Reference yield:

: 47307-26-6,149967-07-7
(S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester

: 120286-23-9
(S)-2-Benzyloxycarbonylamino-4-(diethoxy-phosphoryl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) N-methylmorpholine, ethyl carbonochloridate, 2.) NaBH₄ / 1.) THF, -10 deg C, 1 min; -5 deg C, 15 min, 2.) THF, water, room temp., 3.5 h

2: 60 percent / CrO₃, pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 99 percent / benzene / 1 h / Heating

4: 95 percent / 95percent aq. AcOH / 24 h / Ambient temperature

5: 95 percent / 1,2-dichloro-ethane / 3 h / 70 °C

6: 99 percent / n-Bu₃SnH / benzene / 1.5 h / Heating

With 4-methyl-morpholine; pyridine; chromium(VI) oxide; sodium tetrahydroborate; tri-n-butyl-tin hydride; chloroformic acid ethyl ester; acetic acid; In dichloromethane; 1,2-dichloro-ethane; benzene;
DOI:10.1055/s-1988-27707