diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate

Base Information

Chemical Name:diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate
CAS No.:98376-19-3
Molecular Formula:C₂₅H₂₄N₆O₅S₂
Molecular Weight:552.635
Hs Code.:

Synonyms:diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate

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Chemical Property of diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate

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Technology Process of diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate

There total 10 articles about diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 98376-18-2
diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate-1-oxide

: 98376-19-3
diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate

Guidance literature:: With acetyl chloride; potassium iodide; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;
DOI:10.1016/S0040-4020(01)96571-8

Reference yield: 57.0%

: 98376-17-1
diphenylmethyl(1S,6R,7S)-7-formamido-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate-1-oxide

: 98376-19-3
diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate

Guidance literature:: With acetyl chloride; potassium iodide; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;
DOI:10.1016/S0040-4020(01)96571-8

Reference yield:

: 33748-49-1
diphenylmethyl(6R,7R)-3-bromomethyl-7-formamido-ceph-3-em-4-carboxylate

: 98376-19-3
diphenylmethyl(6R,7S)-7-formamidoceph-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: LiOMe, t-butyl hypochlorite / tetrahydrofuran / 0.1 h / -70 °C

2: 90percent m-chloroperbenzoic acid / 1.) -20 deg C, 5 min; 2.) up to RT, 1 h

3: 63 percent / NaHCO₃ / dimethylformamide / 1 h

4: 73 percent / KI, acetyl chloride (AcCl) / dimethylformamide / 1.5 h / 0 °C

With tert-butylhypochlorite; lithium methanolate; sodium hydrogencarbonate; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96571-8