2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide

Base Information

• Chemical Name: 2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide
• CAS No.: 205536-87-4
• Molecular Formula: C₂₂H₁₆ClN₃O₆S
• Molecular Weight: 485.905
• Mol file: 205536-87-4.mol

Synonyms:2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide

Chemical Property of 2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide

There total 3 articles about 2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-N-(4-sulfamoylphenyl)acetamide (14949-01-0) + alrestatin (51411-04-2) → 2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide (205536-87-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Ambient temperature;

DOI:10.1016/S0223-5234(99)80071-3

Reference yield:

1,8-Naphthalic anhydride (81-84-5) → 2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide (205536-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / dimethylformamide / 2 h / Heating

2: 80 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / Ambient temperature

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(99)80071-3

Reference yield:

sulfanilamide (63-74-1) → 2-Chloro-N-{4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetylsulfamoyl]-phenyl}-acetamide (205536-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 4 h / Heating

2: 80 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / Ambient temperature

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/S0223-5234(99)80071-3

upstream raw materials:

2-chloro-N-(4-sulfamoylphenyl)acetamide

alrestatin

1,8-Naphthalic anhydride

sulfanilamide