ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate

Base Information

Chemical Name:ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate
CAS No.:1383675-43-1
Molecular Formula:C₂₀H₁₈N₄O₃
Molecular Weight:362.388
Hs Code.:

Synonyms:ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate

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Chemical Property of ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate

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Technology Process of ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate

There total 3 articles about ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1383675-27-1
ethyl 3-iodo-4-(N-methylpropiolamido)benzoate

: 622-79-7
benzyl azide

: 1383675-43-1
ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate

Guidance literature:: With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol301307x

Reference yield:

: 1399891-23-6
C₁₀H₈INO₃

: 1383675-43-1
ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.3: -40 - 20 °C

2.1: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; 2.1: Copper-catalyzed azide-alkyne cycloaddition/Ullmann C-C coupling tandem reaction;
DOI:10.1021/ol301307x

Reference yield:

: 62875-84-7
3-iodobenzocaine

: 1383675-43-1
ethyl 1-benzyl-5-methyl-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / ethyl acetate / 6.5 h / 0 °C / Reflux

2.1: n-butyllithium / tetrahydrofuran / -78 °C

2.3: -40 - 20 °C

3.1: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; potassium carbonate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; 3.1: Copper-catalyzed azide-alkyne cycloaddition/Ullmann C-C coupling tandem reaction;
DOI:10.1021/ol301307x