ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
CAS No.:1374341-90-8
Molecular Formula:C₂₅H₂₀F₃N₃O₃
Molecular Weight:467.447
Hs Code.:

Synonyms:ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

There total 5 articles about ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1128269-77-1
ethyl 1-[6-(5-methyl-2-{[(trifluoromethyl)sulfonyl]oxy}phenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1374341-90-8
ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; cesium fluoride; In water; acetonitrile; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1128268-25-6
ethyl 1-[6-(2-hydroxy-5-methylphenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374341-90-8
ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0.42 h / -78 - 20 °C

2: sodium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); cesium fluoride / acetonitrile; water / 3 h / 90 °C / Inert atmosphere

With pyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; cesium fluoride; In dichloromethane; water; acetonitrile;

Reference yield:

: 1128268-23-4
ethyl 1-[6-(2-methoxy-5-methylphenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374341-90-8
ethyl 1-[6-(4'-hydroxy-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 2.25 h / 0 - 20 °C

2: pyridine / dichloromethane / 0.42 h / -78 - 20 °C

3: sodium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); cesium fluoride / acetonitrile; water / 3 h / 90 °C / Inert atmosphere

With pyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); boron tribromide; sodium carbonate; cesium fluoride; In dichloromethane; water; acetonitrile;