3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one

Base Information

• Chemical Name: 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one
• CAS No.: 1574538-36-5
• Molecular Formula: C₂₄H₂₈N₂O₄
• Molecular Weight: 408.497
• Mol file: 1574538-36-5.mol

Synonyms:3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one

Chemical Property of 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one

There total 5 articles about 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.18%

(±)-3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one (1574538-35-4) → 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one (1574538-36-5) + 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one (1574538-37-6)

Guidance literature:

With CHIRALCEL OD-H column; In ethanol; hexane; Resolution of racemate;

Reference yield:

1-bromo-2-methoxy-4-nitrobenzene (77337-82-7) → 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one (1574538-36-5) + 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one (1574538-37-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 110 °C

2.1: hydrogen; 5%-palladium/activated carbon / methanol / 5 h / 20 °C / Autoclave

3.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.2: AMBERLITE? IRA-400 / 20 h / 20 °C

4.1: caesium carbonate / acetonitrile / 16 h / 60 °C

5.1: CHIRALCEL? OD-H column / ethanol; hexane / Resolution of racemate

With 5%-palladium/activated carbon; hydrogen; potassium carbonate; caesium carbonate; triethylamine; In methanol; ethanol; hexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

3-methoxy-4-morpholin-4-yl-phenylamine (482308-06-5) → 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one (1574538-36-5) + 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one (1574538-37-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / 1,2-dichloro-ethane / 20 °C

1.2: AMBERLITE? IRA-400 / 20 h / 20 °C

2.1: caesium carbonate / acetonitrile / 16 h / 60 °C

3.1: CHIRALCEL? OD-H column / ethanol; hexane / Resolution of racemate

With caesium carbonate; triethylamine; In ethanol; hexane; 1,2-dichloro-ethane; acetonitrile;

upstream raw materials:

4-(2-methoxy-4-nitrophenyl)morpholine

1-bromo-2-methoxy-4-nitrobenzene

3-methoxy-4-morpholin-4-yl-phenylamine

(±)-3-bromo-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one