bromo(4-fluorophenyl)diazirine

Base Information

• Chemical Name: bromo(4-fluorophenyl)diazirine
• CAS No.: 115127-46-3
• Molecular Formula: C₇H₄BrFN₂
• Molecular Weight: 215.025
• Mol file: 115127-46-3.mol

Synonyms:bromo(4-fluorophenyl)diazirine

Chemical Property of bromo(4-fluorophenyl)diazirine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bromo(4-fluorophenyl)diazirine

There total 2 articles about bromo(4-fluorophenyl)diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4-fluorobenzamidine (2339-59-5) → bromo(4-fluorophenyl)diazirine (115127-46-3)

Guidance literature:

With sodium hypobromide; lithium bromide; In hexane; dimethyl sulfoxide; for 1h;

DOI:10.1039/DT9910001417

Reference yield:

4-fluorobenzonitrile (1194-02-1,143234-87-1) → bromo(4-fluorophenyl)diazirine (115127-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) MeONa, 2) NH₄Cl / 1) MeOH, 48 h, rt, 2) 24 h

2: 41 percent / LiBr, aq. sodium hypobromite / dimethylsulfoxide; hexane / 1 h

With sodium hypobromide; sodium methylate; ammonium chloride; lithium bromide; In hexane; dimethyl sulfoxide;

DOI:10.1039/DT9910001417

Reference yield: 65.0%

bromo(4-fluorophenyl)diazirine (115127-46-3) → 3-Fluoro-3-(4-fluoro-phenyl)-3H-diazirine

Guidance literature:

With tetrabutyl ammonium fluoride; In melt;

DOI:10.1002/mrc.1260251018

upstream raw materials:

4-fluorobenzamidine

4-fluorobenzonitrile

Downstream raw materials:

(4-fluorophenyl)methoxydiaziridine