(Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide

Base Information

• Chemical Name: (Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide
• CAS No.: 1319746-23-0
• Molecular Formula: C₂₄H₂₉N₃O₆
• Molecular Weight: 455.511
• Mol file: 1319746-23-0.mol

Synonyms:(Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide

Chemical Property of (Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide

There total 9 articles about (Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

4-amino-2-isopropoxybenzamide (1319746-16-1) + 1-(2-methoxy-4-nitrophenyl)-5-methylhex-2-yn-1-one (1319746-19-4) → (Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide (1319746-23-0)

Guidance literature:

In methanol; at 120 ℃; for 3h;

DOI:10.1021/jo200917d

Reference yield:

2-hydroxy-4-nitrobenzoic acid (619-19-2) → (Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide (1319746-23-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

4.2: 1.25 h / -78 - 20 °C / Inert atmosphere

5.1: methanol / 3 h / 120 °C

With n-butyllithium; oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo200917d

Reference yield:

C10H10ClNO4 → (Z)-2-isopropoxy-4-((1-(2-methoxy-4-nitrophenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)benzamide (1319746-23-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide / dichloromethane / Inert atmosphere

2: platinum(IV) oxide; hydrogen; potassium carbonate / methanol / 0.75 h

3: methanol / 3 h / 120 °C

With platinum(IV) oxide; ammonium hydroxide; hydrogen; potassium carbonate; In methanol; dichloromethane;

DOI:10.1021/jo200917d

upstream raw materials:

4-amino-2-isopropoxybenzamide

1-(2-methoxy-4-nitrophenyl)-5-methylhex-2-yn-1-one

N,2-dimethoxy-N-methyl-4-nitrobenzamide

2-isopropoxy-4-nitrobenzoic acid

Downstream raw materials:

(Z)-4-((1-(4-amino-2-methoxyphenyl)-5-methyl-1-oxohex-2-en-3-yl)amino)-2-isopropoxybenzamide