2-Hydroxy-5-(methoxymethoxy)-3,4-dimethylbenzoic acid

Base Information

Chemical Name:2-Hydroxy-5-(methoxymethoxy)-3,4-dimethylbenzoic acid
CAS No.:816456-21-0
Molecular Formula:C11H14O5
Molecular Weight:226.22586
Hs Code.:
DSSTox Substance ID:DTXSID20464403
Nikkaji Number:J2.242.675C
Wikidata:Q82289702
Mol file:816456-21-0.mol

Synonyms:816456-21-0;2-Hydroxy-5-(methoxymethoxy)-3,4-dimethylbenzoic acid;MKIIZNXJJJJNRZ-UHFFFAOYSA-;DTXSID20464403;Benzoic acid,2-hydroxy-5-(methoxymethoxy)-3,4-dimethyl-(9ci);InChI=1/C11H14O5/c1-6-7(2)10(12)8(11(13)14)4-9(6)16-5-15-3/h4,12H,5H2,1-3H3,(H,13,14)

Suppliers and Price of 2-Hydroxy-5-(methoxymethoxy)-3,4-dimethylbenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Hydroxy-5-(methoxymethoxy)-3,4-dimethylbenzoic acid

Chemical Property:

PSA：75.99000
LogP:1.68990
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:226.08412354
Heavy Atom Count:16
Complexity:243

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(C(=C1C)O)C(=O)O)OCOC

Technology Process of 2-Hydroxy-5-(methoxymethoxy)-3,4-dimethylbenzoic acid

There total 4 articles about 2-Hydroxy-5-(methoxymethoxy)-3,4-dimethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 816456-19-6
ethyl 2-hydroxy-5-methoxymethoxy-3,4-dimethylbenzoate

: 816456-21-0
2-hydroxy-5-methoxymethoxy-3,4-dimethylbenzoic acid

Guidance literature:: With potassium hydroxide; In methanol; at 50 ℃; for 2.5h;
DOI:10.1021/jo048514u

Reference yield:

: 816456-12-9
ethyl 2,5-bis(methoxymethoxy)-3,4-dimethylbenzoate

: 816456-21-0
2-hydroxy-5-methoxymethoxy-3,4-dimethylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / MgBr₂ / benzene / 20 °C

2: 100 percent / KOH / methanol / 2.5 h / 50 °C

With potassium hydroxide; magnesium bromide; In methanol; benzene;
DOI:10.1021/jo048514u

Reference yield:

: 608-43-5
2,3-dimethyl-1,4-dihydroxybenzene

: 816456-21-0
2-hydroxy-5-methoxymethoxy-3,4-dimethylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / NaH / dimethylformamide / 0 - 20 °C

2.1: t-BuLi / hexane; pentane / 3 h / 0 °C

2.2: 84 percent / hexane; pentane / 3 h / 0 °C

3.1: 91 percent / MgBr₂ / benzene / 20 °C

4.1: 100 percent / KOH / methanol / 2.5 h / 50 °C

With potassium hydroxide; tert.-butyl lithium; sodium hydride; magnesium bromide; In methanol; hexane; N,N-dimethyl-formamide; pentane; benzene;
DOI:10.1021/jo048514u