1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol

Base Information

• Chemical Name: 1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol
• CAS No.: 400804-32-2
• Molecular Formula: C₂₆H₃₂IN₅O
• Molecular Weight: 557.477
• Mol file: 400804-32-2.mol

Synonyms:1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol

Chemical Property of 1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol

There total 7 articles about 1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-[2-hydroxy-3-(4-(o-tolyl)piperazin-2-yl)propyl]-3-(4-iodophenyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (400804-05-9) → 1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol (400804-32-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 6h;

DOI:10.1021/jm0496133

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol (400804-32-2)

Guidance literature:

Multi-step reaction with 7 steps

1: p-toluenesulfonic acid / benzene / 10 h / Heating

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

3: aq. HCl / CH₂Cl₂ / 3 h

4: NH₂NH₂ / ethanol / 0 - 20 °C

5: 69 percent / Cs₂CO₃ / 48 h

6: Yb(OTf)3 / CH₂Cl₂ / 24 h / 25 °C

7: 100 percent / CF₃CO₂H / CH₂Cl₂ / 6 h

With hydrogenchloride; caesium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; hydrazine; ytterbium(III) triflate; In ethanol; dichloromethane; benzene;

DOI:10.1021/jm0496133

Reference yield:

4-morpholin-4-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid ter-tbutyl ester (217807-98-2) → 1-[3-(4-iodophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl]-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol (400804-32-2)

Guidance literature:

Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: aq. HCl / CH₂Cl₂ / 3 h

3: NH₂NH₂ / ethanol / 0 - 20 °C

4: 69 percent / Cs₂CO₃ / 48 h

5: Yb(OTf)3 / CH₂Cl₂ / 24 h / 25 °C

6: 100 percent / CF₃CO₂H / CH₂Cl₂ / 6 h

With hydrogenchloride; caesium carbonate; triethylamine; trifluoroacetic acid; hydrazine; ytterbium(III) triflate; In ethanol; dichloromethane;

DOI:10.1021/jm0496133

upstream raw materials:

1-[2-hydroxy-3-(4-(o-tolyl)piperazin-2-yl)propyl]-3-(4-iodophenyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

N-tert-butyloxycarbonylpiperidin-4-one

4-morpholin-4-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid ter-tbutyl ester

3-(4-iodophenyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester