2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester

Base Information

Chemical Name:2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester
CAS No.:118388-74-2
Molecular Formula:C₃₂H₄₁NO₇
Molecular Weight:551.68
Hs Code.:

Synonyms:2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester

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Chemical Property of 2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester

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Technology Process of 2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester

There total 3 articles about 2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37736-82-6
(S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid

: 118388-74-2
2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1-methylpiperidine / ethyl acetate / 0.17 h / -20 °C

2: ethyl acetate; diethyl ether / 2 °C / overnight

3: 86.4 percent / HBr gas / diethyl ether / -20 °C

4: 1.) NaH / 1.) THF, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h

With N-methylcyclohexylamine; hydrogen bromide; sodium hydride; In diethyl ether; ethyl acetate;
DOI:10.1021/jm00164a058

Reference yield:

: 118388-73-1
(S)-2-tert-butyl 1-cyclohexyl-4-diazo-3-oxobutan-2-ylcarbamate

: 118388-74-2
2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86.4 percent / HBr gas / diethyl ether / -20 °C

2: 1.) NaH / 1.) THF, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h

With hydrogen bromide; sodium hydride; In diethyl ether;
DOI:10.1021/jm00164a058

Reference yield:

: C₁₉H₃₃NO₆

: 118388-74-2
2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate; diethyl ether / 2 °C / overnight

2: 86.4 percent / HBr gas / diethyl ether / -20 °C

3: 1.) NaH / 1.) THF, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h

With hydrogen bromide; sodium hydride; In diethyl ether; ethyl acetate;
DOI:10.1021/jm00164a058