1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane

Base Information

Chemical Name:1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane
CAS No.:216244-37-0
Molecular Formula:C₂₆H₄₁FS
Molecular Weight:404.676
Hs Code.:

Synonyms:1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane

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Chemical Property of 1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane

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Technology Process of 1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane

There total 4 articles about 1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 14204-27-4
N-phenylthiophthalimide

: 216244-24-5
1-[trans-4-(2-propenyl)cyclohexyl]-trans-4-pentylcyclohexane

: 216244-37-0
1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane

Guidance literature:: With pyridine; hydrogen fluoride; In dichloromethane; at 20 ℃;
DOI:10.1246/cl.1998.1169

Reference yield:

: 291538-19-7
1-[trans-4-(2-hydroxyethyl)cyclohexyl]-trans-4-pentylcyclohexane

: 216244-37-0
1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

2.1: n-BuLi / hexane; diethyl ether / 4 h / 20 °C

2.2: 72 percent / diethyl ether; hexane / 4 h / 20 °C

3.1: 81 percent / HF/pyridine / CH₂Cl₂ / 20 °C

With pyridine; n-butyllithium; hydrogen fluoride; pyridinium chlorochromate; In diethyl ether; hexane; dichloromethane; 1.1: Oxidation / 2.1: Dehydrobromination / 2.2: Wittig reaction / 3.1: thio-fluorination;
DOI:10.1246/bcsj.73.1633

Reference yield:

: 129738-34-7
1-[trans-4-(ethenyl)cyclohexyl]-trans-4-pentylcyclohexane

: 216244-37-0
1-{trans-4-[2-fluoro-3-(phenylthio)propyl]cyclohexyl}-trans-4-pentylcyclohexane

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane / tetrahydrofuran / 12 h / 20 °C

1.2: 85 percent / H₂O₂; aq. NaOH / tetrahydrofuran / 6 h / 20 °C

2.1: 85 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

3.1: n-BuLi / hexane; diethyl ether / 4 h / 20 °C

3.2: 72 percent / diethyl ether; hexane / 4 h / 20 °C

4.1: 81 percent / HF/pyridine / CH₂Cl₂ / 20 °C

With pyridine; n-butyllithium; hydrogen fluoride; borane; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 1.1: hydroboration / 1.2: Oxidation / 2.1: Oxidation / 3.1: Dehydrobromination / 3.2: Wittig reaction / 4.1: thio-fluorination;
DOI:10.1246/bcsj.73.1633