5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole

Base Information

• Chemical Name: 5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole
• CAS No.: 1182705-92-5
• Molecular Formula: C₂₇H₃₅N₃O₄
• Molecular Weight: 465.593
• Mol file: 1182705-92-5.mol

Synonyms:5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole

Chemical Property of 5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole

There total 4 articles about 5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

piperazine (110-85-0) + 5-[2-(4-bromobutoxy)-4-isopropoxyphenyl]-4-(4-methoxyphenyl)isoxazole (1182705-87-8) → 5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole (1182705-92-5)

Guidance literature:

In ethanol; for 4h; Reflux;

Reference yield:

7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on (485-72-3) → 5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole (1182705-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / ethanol; N,N-dimethyl-formamide / 3 h / Reflux

2: potassium carbonate; hydroxylamine hydrochloride / ethanol / 24 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 - 70 °C

4: ethanol / Reflux

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.2174/1573406411309050015

Reference yield:

7-isopropoxy-3-(4-methoxy-phenyl)-4H-chromen-4-one (354782-83-5) → 5-{4-isopropoxy-2-[4-(piperazin-1-yl)butoxy]phenyl}-4-(4-methoxyphenyl)isoxazole (1182705-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; hydroxylamine hydrochloride / ethanol / 24 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 - 70 °C

3: ethanol / Reflux

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.2174/1573406411309050015

upstream raw materials:

piperazine

5-[2-(4-bromobutoxy)-4-isopropoxyphenyl]-4-(4-methoxyphenyl)isoxazole

7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on

7-isopropoxy-3-(4-methoxy-phenyl)-4H-chromen-4-one