Technology Process of 1,4-dichloro-2,5-bis<4-(2-hydroxymethylphenyl)butyl>-3,6-dimethoxybenzene
There total 10 articles about 1,4-dichloro-2,5-bis<4-(2-hydroxymethylphenyl)butyl>-3,6-dimethoxybenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium borohydride;
In
tetrahydrofuran;
for 8h;
Heating;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: chlorine / iodine
2: lithium aluminium hydride
3: pyridinium chlorochromate
5: hydrogen / Pd/C
6: 82 percent / lithium borohydride / tetrahydrofuran / 8 h / Heating
With
lithium aluminium tetrahydride; lithium borohydride; hydrogen; chlorine; pyridinium chlorochromate;
palladium on activated charcoal; iodine;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 58 percent / chlorine / iodine / CH2Cl2 / 0.5 h / 20 °C
2: 1.) n-butyllithium / 1.) THF, hexane, reflux, 2.) THF, reflux, 6 h
3: 1.) sodium methanolate / 1.) methanol, reflux, 2.) THF, reflux, 2 h
4: hydrogen / 5 percent Pd/C / ethyl acetate; methanol / 2.5 h / Heating
5: 82 percent / lithium borohydride / tetrahydrofuran / 8 h / Heating
With
lithium borohydride; n-butyllithium; hydrogen; sodium methylate; chlorine;
palladium on activated charcoal; iodine;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
