Acetamide, N-((3-amino-4-methylphenyl)methyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-, hydrate

Base Information

• Chemical Name: Acetamide, N-((3-amino-4-methylphenyl)methyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-, hydrate
• CAS No.: 74101-73-8
• Molecular Formula: C₂₀H₂₆N₂O₃
• Molecular Weight: 342.438
• DSSTox Substance ID: DTXSID20225051
• Wikidata: Q83103947
• Mol file: 74101-73-8.mol

Synonyms:2-Methyl-5-(beta-(N'-acetyl-3',4'-dimethoxyphenylethylamino)methyl)aniline hydrate;Acetamide, N-((3-amino-4-methylphenyl)methyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-, hydrate;74101-73-8;C20H26N2O3.H2O;DTXSID20225051;LS-8066;C20-H26-N2-O3.H2-O

Chemical Property of Acetamide, N-((3-amino-4-methylphenyl)methyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-, hydrate

Chemical Property:

• Vapor Pressure: 1.28E-11mmHg at 25°C
• Boiling Point: 537.4°C at 760 mmHg
• Flash Point: 278.8°C
• Density: 1.128g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 342.19434270
• Heavy Atom Count: 25
• Complexity: 418

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)CN(CCC2=CC(=C(C=C2)OC)OC)C(=O)C)N

Technology Process of Acetamide, N-((3-amino-4-methylphenyl)methyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-, hydrate

There total 4 articles about Acetamide, N-((3-amino-4-methylphenyl)methyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-, hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methyl-5-(-methyl)-nitrobenzol (74101-71-6) → 2-Methyl-5-<β-(N'-acetyl-3',4'-dimethoxy-phenylethylamino)-methyl>-anilin (74101-73-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

(4-Methyl-3-nitro-phenyl)-methanol (40870-59-5) → 2-Methyl-5-<β-(N'-acetyl-3',4'-dimethoxy-phenylethylamino)-methyl>-anilin (74101-73-8)

Guidance literature:

Multi-step reaction with 4 steps

1: PBr₃ / benzene

2: benzene

4: H₂ / Pd-C / ethanol

With hydrogen; phosphorus tribromide; palladium on activated charcoal; In ethanol; benzene;

Reference yield:

2-Methyl-5-<β-(3',4'-dimethoxy-phenylethylamino)-methyl>-nitrobenzol (74101-70-5) → 2-Methyl-5-<β-(N'-acetyl-3',4'-dimethoxy-phenylethylamino)-methyl>-anilin (74101-73-8)

Guidance literature:

Multi-step reaction with 2 steps

2: H₂ / Pd-C / ethanol

With hydrogen; palladium on activated charcoal; In ethanol;

upstream raw materials:

2-Methyl-5-(-methyl)-nitrobenzol

(4-Methyl-3-nitro-phenyl)-methanol

2-Methyl-5-<β-(3',4'-dimethoxy-phenylethylamino)-methyl>-nitrobenzol

4-bromomethyl-1-methyl-2-nitro-benzene