2-benzothienyl trifluoromethyl ketone O-tosyl oxime

Base Information

• Chemical Name: 2-benzothienyl trifluoromethyl ketone O-tosyl oxime
• CAS No.: 947733-02-0
• Molecular Formula: C₁₇H₁₂F₃NO₃S₂
• Molecular Weight: 399.414
• Mol file: 947733-02-0.mol

Synonyms:2-benzothienyl trifluoromethyl ketone O-tosyl oxime

Chemical Property of 2-benzothienyl trifluoromethyl ketone O-tosyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-benzothienyl trifluoromethyl ketone O-tosyl oxime

There total 2 articles about 2-benzothienyl trifluoromethyl ketone O-tosyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzothienyl trifluoromethyl ketone oxime (138395-49-0) + p-toluenesulfonyl chloride (98-59-9) → 2-benzothienyl trifluoromethyl ketone O-tosyl oxime (947733-02-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1.2h;

DOI:10.1021/ol071290s

Reference yield:

1-(benzo[b]thiophen-2-yl)-2,2,2-trifluoroethan-1-one (75277-97-3) → 2-benzothienyl trifluoromethyl ketone O-tosyl oxime (947733-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH*HCl; pyridine / 2 h / Heating

2: Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.2 h / 20 °C

With pyridine; dmap; hydroxylamine hydrochloride; triethylamine; In dichloromethane;

DOI:10.1021/ol071290s

upstream raw materials:

2-benzothienyl trifluoromethyl ketone oxime

p-toluenesulfonyl chloride

1-(benzo[b]thiophen-2-yl)-2,2,2-trifluoroethan-1-one