(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Base Information

Chemical Name:(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine
CAS No.:335381-92-5
Molecular Formula:C₂₅H₂₉N₅O₆
Molecular Weight:495.535
Hs Code.:

Synonyms:(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Suppliers and Price of (2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

There total 10 articles about (2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 335381-92-5
(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Guidance literature:

Reference yield:

: 335382-02-0
(2S)-2-methyl-2-dimethoxymethyl-6-nitro-2H-1-benzopyran

: 335381-92-5
(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH / toluene / Heating

2: (S,S)-Mn(III)-salen complex; NaOCl; Na₂HPO₄ / CH₂Cl₂ / 0 - 20 °C

3: aq. NH₃ / ethanol / 50 °C

4: Et₃N / dimethylformamide; propan-2-ol / 20 °C

5: propan-2-ol

With ammonium hydroxide; sodium hypochlorite; disodium hydrogenphosphate; (S,S)-Mn(III)-salen; toluene-4-sulfonic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/jm010183f

Reference yield:

: 146821-83-2
3,4-dihydro-2-dimethoxymethyl-4-hydroxy-2-methyl-6-nitro-2H-1-benzopyran

: 335381-92-5
(2S,3S,4R)-N''-cyano-N-(6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-([1,3]-5,5-dimethyldioxan-2-yl)-2H-benzopyran-4-yl)-N'-benzylguanidine

Guidance literature:: Multi-step reaction with 9 steps

1: 28 percent / DCC; DMAP / ethyl acetate / 1 h / 20 °C

2: 99 percent / 1N aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C

3: i-Pr₂NEt / CH₂Cl₂ / 15 h / 20 °C

4: DBU / toluene / Heating

5: p-TsOH / toluene / Heating

6: (S,S)-Mn(III)-salen complex; NaOCl; Na₂HPO₄ / CH₂Cl₂ / 0 - 20 °C

7: aq. NH₃ / ethanol / 50 °C

8: Et₃N / dimethylformamide; propan-2-ol / 20 °C

9: propan-2-ol

With dmap; lithium hydroxide; ammonium hydroxide; sodium hypochlorite; disodium hydrogenphosphate; (S,S)-Mn(III)-salen; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/jm010183f