C₁₇H₁₈Br₂O₄

Base Information

• Chemical Name: C₁₇H₁₈Br₂O₄
• CAS No.: 1350889-88-1
• Molecular Formula: C₁₇H₁₈Br₂O₄
• Molecular Weight: 446.136
• Mol file: 1350889-88-1.mol

Synonyms:C₁₇H₁₈Br₂O₄

Chemical Property of C₁₇H₁₈Br₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₈Br₂O₄

There total 6 articles about C₁₇H₁₈Br₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C17H18O4 (1350889-87-0) → C17H18Br2O4 (1350889-88-1)

Guidance literature:

With bromine; sodium hydrogencarbonate; In tetrachloromethane; at 20 ℃; for 0.333333h;

DOI:10.1016/j.bmcl.2011.09.067

Reference yield:

(+)-proto-quercitol (488-73-3) → C17H18Br2O4 (1350889-88-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 10-camphorsufonic acid / acetone / 19 h / 20 °C

2: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 4.5 h / 0 - 20 °C

3: pyridinium p-toluenesulfonate / methanol / 23 h / 4 °C

4: pyridine / 21 h / 0 - 20 °C

5: n-butyllithium / tetrahydrofuran / 21 h / -78 - 4 °C

6: bromine; sodium hydrogencarbonate / tetrachloromethane / 0.33 h / 20 °C

With pyridine; n-butyllithium; 10-camphorsufonic acid; bromine; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; acetone; 2: Parikh-Doering oxidation / 5: Wittig reaction;

DOI:10.1016/j.bmcl.2011.09.067

Reference yield:

1,2:3,4-di-O-isopropylidene-5R-(+)-proto-quercitol (1157852-09-9) → C17H18Br2O4 (1350889-88-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 4.5 h / 0 - 20 °C

2: pyridinium p-toluenesulfonate / methanol / 23 h / 4 °C

3: pyridine / 21 h / 0 - 20 °C

4: n-butyllithium / tetrahydrofuran / 21 h / -78 - 4 °C

5: bromine; sodium hydrogencarbonate / tetrachloromethane / 0.33 h / 20 °C

With pyridine; n-butyllithium; bromine; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; 1: Parikh-Doering oxidation / 4: Wittig reaction;

DOI:10.1016/j.bmcl.2011.09.067

upstream raw materials:

1,2:3,4-di-O-isopropylidene-5R-(+)-proto-quercitol

C₃₀H₂₆O₈

C₁₇H₁₈O₄

(+)-proto-quercitol

Downstream raw materials:

C₂₄H₂₃BrO₆

(1R,2S,3S,4S)-5-hydroxymethyl-1-octylamino-2,3,4-trihydroxycyclohex-5-ene