8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine

Base Information

Chemical Name:8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine
CAS No.:220445-46-5
Molecular Formula:C₁₈H₁₃ClN₄O₂
Molecular Weight:352.78
Hs Code.:

Synonyms:8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine

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Chemical Property of 8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine

Chemical Property:

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Technology Process of 8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine

There total 6 articles about 8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220445-45-4
4-(acetaminomethyl)-8-chloro-1-(4-nitrophenyl)-5H-2,3-benzodiazepine

: 220445-46-5
8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine

Guidance literature:: With trichlorophosphate; In 1,2-dichloro-ethane; for 3h; Heating;
DOI:10.1016/S0968-0896(00)00133-4

Reference yield:

: 220445-50-1
4-(Aminomethyl)-8-chloro-1-(4-nitrophenyl)-5H-2,3-benzodiazepine

: 220445-46-5
8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 0.60 g / 2 h

2: POCl₃ / 1,2-dichloro-ethane / 3 h / Heating

With trichlorophosphate; In 1,2-dichloro-ethane; 1: Acetylation / 2: Cyclization;
DOI:10.1016/S0968-0896(00)00133-4

Reference yield:

: 200419-71-2
8-Chloro-4-methyl-1-(4-nitrophenyl)-5H-2,3-benzodiazepine

: 220445-46-5
8-chloro-3-methyl-6-(4-nitrophenyl)-11H-imidazolo[3,4-c][2,3]-benzodiazepine

Guidance literature:: Multi-step reaction with 6 steps

1: 29 percent / SeO₂ / dioxane / 0.67 h / 90 °C

2: 1.62 g / NaBH₄ / tetrahydrofuran; H₂O / 0.67 h / 20 °C

3: 1.34 g / PPh₃; DEAD / tetrahydrofuran / 3 h / 20 °C

4: 0.97 g / NH₂NH₂*H₂O / methanol / 4 h / Heating

5: 0.60 g / 2 h

6: POCl₃ / 1,2-dichloro-ethane / 3 h / Heating

With sodium tetrahydroborate; selenium(IV) oxide; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; 1: Oxidation / 2: Reduction / 3: Substitution / 4: Reduction / 5: Acetylation / 6: Cyclization;
DOI:10.1016/S0968-0896(00)00133-4