(E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide

Base Information

• Chemical Name: (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide
• CAS No.: 1609084-39-0
• Molecular Formula: C₂₇H₂₆FNO₇
• Molecular Weight: 495.504
• Mol file: 1609084-39-0.mol

Synonyms:(E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide

Chemical Property of (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide

There total 7 articles about (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(4-fluorophenyl)acryloyl chloride (13565-08-7) + (3-amino-4,5-dimethoxyphenyl)(3,4,5-trimethoxyphenyl)methanone (1609084-44-7) → (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide (1609084-39-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmcl.2014.03.076

Reference yield:

C18H19NO8 (1609084-43-6) → (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide (1609084-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; hydrogenchloride / acetic acid; water; ethanol / 1 h / Reflux

2: triethylamine / dichloromethane; tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; iron; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid;

DOI:10.1016/j.bmcl.2014.03.076

Reference yield:

(3,4-dimethoxy-5-nitrophenyl)(3,4,5-trimethoxyphenyl)methanol (1609084-42-5) → (E)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxybenzoyl)phenyl)-3-(4-fluorophenyl)acrylamide (1609084-39-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dipyridinium dichromate / dichloromethane / 8 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

2: iron; hydrogenchloride / acetic acid; water; ethanol / 1 h / Reflux

3: triethylamine / dichloromethane; tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dipyridinium dichromate; iron; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid;

DOI:10.1016/j.bmcl.2014.03.076

upstream raw materials:

(3,4-dimethoxy-5-nitrophenyl)(3,4,5-trimethoxyphenyl)methanol

C₁₈H₁₉NO₈

(E)-3-(4-fluorophenyl)acryloyl chloride

(3-amino-4,5-dimethoxyphenyl)(3,4,5-trimethoxyphenyl)methanone