2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone

Base Information

Chemical Name:2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone
CAS No.:1443435-59-3
Molecular Formula:C₂₅H₂₂F₂N₄OS
Molecular Weight:464.539
Hs Code.:

Synonyms:2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone

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Chemical Property of 2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone

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Technology Process of 2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone

There total 6 articles about 2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443436-06-3
(1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt

: 1443256-56-1
5,6,7,8-tetrahydro-4H-thiazolo-[4,5-d]-azepin-2-ylamine hydrobromide

: 1443435-59-3
2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1443435-90-2
N-(4-fluoro-phenyl)-N-(2-(4-fluoro-phenyl)-2-oxo-ethyl)-malonamic acid ethyl ester

: 1443435-59-3
2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate; acetic acid / 4 h / Reflux

2: lithium hydroxide / 1,4-dioxane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

With ammonium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 146537-23-7
1-(4-fluoro-phenyl)-2-(4-fluoro-phenylamino)-ethanone

: 1443435-59-3
2-[1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl]-1-(2-methyl-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 5 - 20 °C

2: ammonium acetate; acetic acid / 4 h / Reflux

3: lithium hydroxide / 1,4-dioxane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

With ammonium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;