N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

Base Information

Chemical Name:N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate
CAS No.:956931-97-8
Molecular Formula:C₂HF₃O₂*C₂₉H₃₂F₃N₃O₅
Molecular Weight:673.609
Hs Code.:

Synonyms:N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

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Chemical Property of N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

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Technology Process of N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

There total 3 articles about N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: cyclopentyl N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucinate

: 956931-97-8
N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

Guidance literature:: cyclopentyl N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucinate; With lithium hydroxide; water; In tetrahydrofuran; at 20 - 80 ℃; for 26h;

With hydrogenchloride; In water; pH=7;

Reference yield:

: 602311-69-3
6-amino-5-(2,4-difluorobenzoyl)-1-(2,6-difluoro-4-hydroxy-phenyl)-1H-pyridin-2-one

: 956931-97-8
N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 40 °C

2.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 h / 90 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 26 h / 20 - 80 °C

3.2: pH 7

With lithium hydroxide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 54512-75-3
1-bromo-5-chloropentane

: 956931-97-8
N-(5-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 40 °C

2.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 h / 90 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 26 h / 20 - 80 °C

3.2: pH 7

With lithium hydroxide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;