[1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester

Base Information

• Chemical Name: [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester
• CAS No.: 22730-59-2
• Molecular Formula: C₁₆H₂₁ClNO₅P
• Molecular Weight: 373.773

Synonyms:[1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester

Chemical Property of [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester

Chemical Property:

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Technology Process of [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester

There total 3 articles about [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl (E)-3-(4-chlorophenyl)-2-cyanoacrylate (2169-68-8) + phosphonic acid diethyl ester (762-04-9) → [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester (22730-59-2)

Guidance literature:

nanoflake zinc oxide; at 50 ℃; for 7.5h;

DOI:10.1016/j.tet.2008.03.095

Reference yield: 90.0%

4-chlorobenzaldehyde (104-88-1) + phosphonic acid diethyl ester (762-04-9) + ethyl 2-cyanoacetate (105-56-6) → [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester (22730-59-2)

Guidance literature:

With 1,4-diazabicyclo[2.2.2]octane hydroacetate; In neat (no solvent); at 25 ℃; for 0.833333h; Green chemistry;

DOI:10.1039/c5ra02743h

Reference yield: 87.0%

4-chlorobenzaldehyde (104-88-1) + ethyl 2-cyanoacetate (105-56-6) + triethyl phosphite (122-52-1) → [1-(4-chlorophenyl)-2-cyano-2-ethylcarboxylic acid ethyl ester]phosphonic acid diethyl ester (22730-59-2)

Guidance literature:

With lithium bromide; In water; for 4h; Reflux;

DOI:10.1080/10426507.2019.1702988

upstream raw materials:

ethyl (E)-3-(4-chlorophenyl)-2-cyanoacrylate

phosphonic acid diethyl ester

4-chlorobenzaldehyde

ethyl 2-cyanoacetate

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