(2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Base Information

• Chemical Name: (2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
• CAS No.: 1027514-09-5
• Molecular Formula: C₂₂H₂₂FNO₅
• Molecular Weight: 399.419
• Mol file: 1027514-09-5.mol

Synonyms:(2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Chemical Property of (2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

There total 1 articles about (2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,5R)-3-(4'-Fluoro-biphenyl-4-yl)-5-hydroxymethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester → (2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (1027514-09-5)

Guidance literature:

With chromium(VI) oxide; periodic acid; In acetonitrile; at 0 ℃;

DOI:10.1021/jm0001368

Reference yield:

(2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (1027514-09-5) → (2R, 4S)-4-(4'-fluorobiphenyl-4-yl)-5-oxopyrrolidine-2-carboxylic acid hydroxyamide

Guidance literature:

Multi-step reaction with 3 steps

1: BOP; i-Pr₂NEt / CH₂Cl₂

2: HCl / CH₂Cl₂

3: H₂ / 5percent Pd/BaSO₄ / methanol / 2280.15 Torr

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 5percent Pd/BaSO₄; In methanol; dichloromethane; 1: Acylation / 2: acidolysis / 3: debenzylation;

DOI:10.1021/jm0001368

Reference yield:

(2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (1027514-09-5) → (2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-2-carboxylic acid benzyloxy-amide (287476-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: BOP; i-Pr₂NEt / CH₂Cl₂

2: HCl / CH₂Cl₂

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Acylation / 2: acidolysis;

DOI:10.1021/jm0001368

Downstream raw materials:

(2R,4S)-4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-2-carboxylic acid benzyloxy-amide