4-[4-(Phenylmethyl)-1-piperazinyl]benzenemethanamine

Base Information

Chemical Name:4-[4-(Phenylmethyl)-1-piperazinyl]benzenemethanamine
CAS No.:889951-30-8
Molecular Formula:C₁₈H₂₃N₃
Molecular Weight:281.401
Hs Code.:
DSSTox Substance ID:DTXSID101217974
Mol file:889951-30-8.mol

Synonyms:889951-30-8;4-[4-(Phenylmethyl)-1-piperazinyl]benzenemethanamine;DTXSID101217974;AKOS000318402

Suppliers and Price of 4-[4-(Phenylmethyl)-1-piperazinyl]benzenemethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[4-(Phenylmethyl)-1-piperazinyl]benzenemethanamine

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:281.189197746
Heavy Atom Count:21
Complexity:285

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CC2=CC=CC=C2)C3=CC=C(C=C3)CN

Technology Process of 4-[4-(Phenylmethyl)-1-piperazinyl]benzenemethanamine

There total 3 articles about 4-[4-(Phenylmethyl)-1-piperazinyl]benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90905-00-3
4-(4-benzylpiperazin-1-yl)benzonitrile

: 889951-30-8
4-(4-benzyl-piperazin-1-yl)-benzylamine

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 20 ℃; for 3h;
DOI:10.1021/jm050765n

Reference yield:

: 2759-28-6
1-phenylmethylpiperazine

: 889951-30-8
4-(4-benzyl-piperazin-1-yl)-benzylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃ / dimethylsulfoxide / 8 h / 90 °C

2: Red-Al / tetrahydrofuran; toluene / 3 h / 20 °C

With potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jm050765n

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 889951-30-8
4-(4-benzyl-piperazin-1-yl)-benzylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃ / dimethylsulfoxide / 8 h / 90 °C

2: Red-Al / tetrahydrofuran; toluene / 3 h / 20 °C

With potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jm050765n