{4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid

Base Information

Chemical Name:{4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid
CAS No.:886439-58-3
Molecular Formula:C₂₂H₂₀N₄O₇
Molecular Weight:452.423
Hs Code.:

{4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1<i>H</i>-purin-8-yl]-phenoxy}-acetic acid

Synonyms:{4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid

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Chemical Property of {4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid

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Technology Process of {4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid

There total 6 articles about {4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 6-amino-5-(4-carboxymethyloxybenzylideneamino)-1-(2-hydroxy-3-phenoxypropyl)uracil

: 886439-58-3
{4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid

Guidance literature:: With diethylazodicarboxylate; In 1,2-dimethoxyethane; for 0.916667h; Heating;
DOI:10.1016/j.bmc.2005.11.050

Reference yield:

: 32968-43-7
5-(phenoxymethyl)-2-amino-2-oxazoline

: 886439-58-3
{4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 43 percent / sodium; methanol / 5 h / Heating

2: 83 percent / sodium nitrite; acetic acid / H₂O / 1.5 h / 20 - 60 °C

3: 83 percent / sodium; ethanol / 8 h / Heating

4: 68 percent / sodium dithionite / H₂O / 0.5 h / Heating

5: 57 percent / acetic acid / ethanol / 4 h / Heating

6: 60 percent / diethyl azodicarboxylate / 1,2-dimethoxy-ethane / 0.92 h / Heating

With methanol; sodium dithionite; ethanol; sodium; acetic acid; sodium nitrite; diethylazodicarboxylate; In 1,2-dimethoxyethane; ethanol; water; 1: Pinner reaction;
DOI:10.1016/j.bmc.2005.11.050

Reference yield:

: 886439-93-6
5-amino-2-phenoxymethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

: 886439-58-3
{4-[3-(2-hydroxy-3-phenoxy-propyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxy}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / sodium nitrite; acetic acid / H₂O / 1.5 h / 20 - 60 °C

2: 83 percent / sodium; ethanol / 8 h / Heating

3: 68 percent / sodium dithionite / H₂O / 0.5 h / Heating

4: 57 percent / acetic acid / ethanol / 4 h / Heating

5: 60 percent / diethyl azodicarboxylate / 1,2-dimethoxy-ethane / 0.92 h / Heating

With sodium dithionite; ethanol; sodium; acetic acid; sodium nitrite; diethylazodicarboxylate; In 1,2-dimethoxyethane; ethanol; water;
DOI:10.1016/j.bmc.2005.11.050