4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde

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Chemical Name:4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde
CAS No.:1350376-49-6
Molecular Formula:C₃₀H₂₅ClFN₃O₅S₂
Molecular Weight:626.129
Hs Code.:

Synonyms:4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde

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Chemical Property of 4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde

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Technology Process of 4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde

There total 7 articles about 4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350375-65-3
5-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole

: 1350376-49-6
4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 0.25 h

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 1.5 h / 65 °C / Inert atmosphere

With sodium hydrogencarbonate; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1350376-49-6
4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

1.2: 1 h

2.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 70 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

3.2: 0.25 h

4.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 1.5 h / 65 °C / Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350375-62-0
2-(1-(methoxymethoxy)cyclobutyl)thiazole

: 1350376-49-6
4-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-fluorobenzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 70 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

3.2: 0.25 h

4.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 1.5 h / 65 °C / Inert atmosphere

With sodium hydrogencarbonate; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;