8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline

Base Information

Chemical Name:8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline
CAS No.:1718-87-2
Molecular Formula:C₂₀H₂₀N₂O₃
Molecular Weight:336.39
Hs Code.:

8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-<i>a</i>]isoquinoline

Synonyms:8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline

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Chemical Property of 8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline

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Technology Process of 8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline

There total 5 articles about 8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1357856-72-4
C₂₀H₂₄N₂O₅

: 1718-87-2
8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline

Guidance literature:: C₂₀H₂₄N₂O₅; With methanesulfonic acid; phosphorus pentoxide; at 75 ℃; for 4h;

With sodium hydrogencarbonate; at 20 ℃;
DOI:10.1016/j.tetlet.2011.12.050

Reference yield:

: 14301-36-1
N-[2-(3,4-dimethoxyphenyl)ethyl]formamide

: 1718-87-2
8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; trichlorophosphate / tetrahydrofuran

2.1: trifluoroethanol / 0.5 h / 60 °C

2.2: 4 h / 60 °C

3.1: methanesulfonic acid; phosphorus pentoxide / 4 h / 75 °C

3.2: 20 °C

With methanesulfonic acid; phosphorus pentoxide; triethylamine; trichlorophosphate; In tetrahydrofuran; trifluoroethanol; 2.1: Ugi condensation / 2.2: Ugi condensation;
DOI:10.1016/j.tetlet.2011.12.050

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1718-87-2
8,9-dimethoxy-1-(4-methoxy-phenyl)-5,6-dihydro-imidazo[5,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: Reflux

2.1: triethylamine; trichlorophosphate / tetrahydrofuran

3.1: trifluoroethanol / 0.5 h / 60 °C

3.2: 4 h / 60 °C

4.1: methanesulfonic acid; phosphorus pentoxide / 4 h / 75 °C

4.2: 20 °C

With methanesulfonic acid; phosphorus pentoxide; triethylamine; trichlorophosphate; In tetrahydrofuran; trifluoroethanol; 3.1: Ugi condensation / 3.2: Ugi condensation;
DOI:10.1016/j.tetlet.2011.12.050