8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one

Base Information

Chemical Name:8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one
CAS No.:1221486-04-9
Molecular Formula:C₂₆H₂₃F₂NO₃
Molecular Weight:435.47
Hs Code.:

Synonyms:8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one

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Chemical Property of 8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one

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Technology Process of 8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one

There total 8 articles about 8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1221486-66-3
8-chloro-1-(tetrahydropyran-4-yloxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1221486-04-9
8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one

Guidance literature:: With palladium diacetate; sodium t-butanolate; XPhos; In toluene; tert-butyl alcohol; at 90 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm300327h

Reference yield:

: 1221486-61-8
2-[2-(3-chlorophenyl)-vinyl]-3-methoxybenzoic acid

: 1221486-04-9
8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; Pd-BaSO₄; hydrogen / methanol / 48 h / 20 °C

2.1: thionyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: hydrogen bromide; acetic acid / water / 0.75 h / Reflux

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

5.1: palladium diacetate; sodium t-butanolate; XPhos / toluene; tert-butyl alcohol / 2 h / 90 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; di-isopropyl azodicarboxylate; Pd-BaSO₄; hydrogen bromide; hydrogen; palladium diacetate; acetic acid; triphenylphosphine; sodium t-butanolate; XPhos; In tetrahydrofuran; methanol; dichloromethane; water; toluene; tert-butyl alcohol; 5.1: Buchwald-Hartwig reaction;
DOI:10.1021/jm300327h

Reference yield:

: 1221486-64-1
8-chloro-1-hydroxy-10,11-dihydrodibenzo[a,d]cyclohepten-5-one

: 1221486-04-9
8-(2,4-difluorophenylamino)-1-(tetrahydropyran-4-yloxy)-10,11-dihydro-dibenzo-[a,d]cyclohepten-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2: palladium diacetate; sodium t-butanolate; XPhos / toluene; tert-butyl alcohol / 2 h / 90 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; palladium diacetate; triphenylphosphine; sodium t-butanolate; XPhos; In tetrahydrofuran; toluene; tert-butyl alcohol; 2: Buchwald-Hartwig reaction;
DOI:10.1021/jm300327h