(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester

Base Information

Chemical Name:(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester
CAS No.:346426-62-8
Molecular Formula:C₂₂H₂₇N₂O₆P
Molecular Weight:446.44
Hs Code.:

Synonyms:(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester

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Chemical Property of (benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester

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Technology Process of (benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester

There total 4 articles about (benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 346426-66-2
(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid

: 619-73-8
4-nitrobenzyl chloride

: 346426-62-8
(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 10h;
DOI:10.1021/ja015632f

Reference yield:

: 65577-37-9
[(diphenylmethyl)amino-cyclohexyl-methyl]phosphinic acid

: 346426-62-8
(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.17 g / aq.HBr / 1.5 h / Heating

2: 77 percent / aq.NaOH / dioxane; H₂O / 8 h / 20 °C / pH 9 - 9.5

3: 82 percent / CH₂Cl₂ / 10 h / 20 °C

With sodium hydroxide; hydrogen bromide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ja015632f

Reference yield:

: 65577-02-8
(amino-cyclohexyl-methyl)phosphinic acid

: 346426-62-8
(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / aq.NaOH / dioxane; H₂O / 8 h / 20 °C / pH 9 - 9.5

2: 82 percent / CH₂Cl₂ / 10 h / 20 °C

With sodium hydroxide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ja015632f