(7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol

Base Information

Chemical Name:(7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol
CAS No.:250598-92-6
Molecular Formula:C₂₃H₂₆O₄
Molecular Weight:366.457
Hs Code.:

Synonyms:(7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol

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Chemical Property of (7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol

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Technology Process of (7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol

There total 8 articles about (7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 250598-91-5
(7S)-3,6-anhydro-7-O-benzyl-4,5-O-isopropylidene-1,2-bis-O-(methylsulfonyl)-7-C-phenyl-D-glycero-D-galacto-heptitol

: 250598-92-6
(7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol

Guidance literature:: With sodium iodide; In butanone; for 12h; Heating;
DOI:10.1016/S0968-0896(99)00164-9

Reference yield:

: 7757-38-2,14131-84-1,23262-78-4,27108-13-0,33823-04-0,34685-42-2,57819-52-0,78039-08-4,78039-12-0,78964-16-6,94842-76-9,149342-31-4
2,3,5,6-di-O-isopropylidene-D-mannofuranose

: 250598-92-6
(7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol

Guidance literature:: Multi-step reaction with 9 steps

1: NaH / dimethylsulfoxide / 1 h / 0 - 20 °C

2: 26 percent / NaH / dimethylformamide / 0.5 h / 0 °C

3: 95 percent / H₂ / 10 percent Pd-BaSO₄ / methanol / 4 h

4: DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 1 h / -78 °C

5: 58 percent / tetrahydrofuran / 4 h / 0 °C

6: 90 percent / NaH / dimethylformamide / 0.5 h / 20 °C

7: 85 percent / AcOH / H₂O / 8 h / 20 °C

8: 85 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

9: 82 percent / NaI / butan-2-one / 12 h / Heating

With oxalyl dichloride; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; sodium iodide; palladium on barium sulfate; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone; 1: Substitution / 2: Alkylation / 3: Catalytic hydrogenation / 4: Oxidation / 5: Grignard reaction / 6: Alkylation / 7: Ring cleavage / 8: mesylation / 9: Elimination;
DOI:10.1016/S0968-0896(99)00164-9

Reference yield:

: 250598-83-5
[(3aR,6R,6aS)-6-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-methanol

: 250598-92-6
(7S)-3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-7-C-phenyl-D-altro-hept-1-enitol

Guidance literature:: Multi-step reaction with 8 steps

1: 26 percent / NaH / dimethylformamide / 0.5 h / 0 °C

2: 95 percent / H₂ / 10 percent Pd-BaSO₄ / methanol / 4 h

3: DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 1 h / -78 °C

4: 58 percent / tetrahydrofuran / 4 h / 0 °C

5: 90 percent / NaH / dimethylformamide / 0.5 h / 20 °C

6: 85 percent / AcOH / H₂O / 8 h / 20 °C

7: 85 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

8: 82 percent / NaI / butan-2-one / 12 h / Heating

With oxalyl dichloride; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; sodium iodide; palladium on barium sulfate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; butanone; 1: Alkylation / 2: Catalytic hydrogenation / 3: Oxidation / 4: Grignard reaction / 5: Alkylation / 6: Ring cleavage / 7: mesylation / 8: Elimination;
DOI:10.1016/S0968-0896(99)00164-9