Technology Process of (2S,3aR,6S,7aR)-6-hydroxy-2,3,3a,6,7,7a-hexahydroindole-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
There total 4 articles about (2S,3aR,6S,7aR)-6-hydroxy-2,3,3a,6,7,7a-hexahydroindole-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; formic acid; triethylamine;
tribenzylphosphine;
In
tetrahydrofuran;
for 16h;
Heating;
DOI:10.1021/ja028603t
- Guidance literature:
-
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; triethylamine; tribenzylphosphine;
formic acid;
In
tetrahydrofuran;
for 16h;
Heating;
DOI:10.1021/ja044280k
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 26 g / dimethylaminopyridine; pyridine / CH2Cl2 / 20 h / Heating
2: 97 percent / cerium(III) chloride heptahydrate; NaBH4 / tetrahydrofuran; methanol / 15 h / 0 °C
3: 93 percent / Pd2(dba)3*CHCl3; tribenzylphosphine; triethylamine / formic acid / tetrahydrofuran / 16 h / Heating
With
pyridine; dmap; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium tetrahydroborate; cerium(III) chloride; triethylamine; tribenzylphosphine;
formic acid;
In
tetrahydrofuran; methanol; dichloromethane;
2: Luche reduction;
DOI:10.1021/ja044280k
