6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine

Base Information

• Chemical Name: 6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine
• CAS No.: 304858-51-3
• Molecular Formula: C₁₁H₁₁BrF₃NO
• Molecular Weight: 310.114
• Mol file: 304858-51-3.mol

Synonyms:6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine

Chemical Property of 6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine

There total 1 articles about 6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trifluoro-1-methoxy-ethanol (431-46-9) + 2-(2-amino-5-bromophenyl)-propan-2-ol (304853-89-2) → 6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine (304858-51-3) + 3-[4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-6-yl]-5-fluorobenzonitrile

Guidance literature:

With magnesium sulfate; In toluene;

Reference yield: 73.0%

6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine (304858-51-3) + (3-cyano-5-fluorophenyl)boronic acid → 3-[4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-6-yl]-5-fluorobenzonitrile

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 50 - 85 ℃; for 1.25h;

Reference yield:

3-chlorophenylboronic acid (63503-60-6) + 6-bromo-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine (304858-51-3) → 6-(3-chlorophenyl)-4,4-dimethyl-2-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazine

Guidance literature:

upstream raw materials:

2,2,2-trifluoro-1-methoxy-ethanol

2-(2-amino-5-bromophenyl)-propan-2-ol