tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate
CAS No.:1126403-30-2
Molecular Formula:C₂₄H₂₉N₅O₃
Molecular Weight:435.526
Hs Code.:
Mol file:1126403-30-2.mol

Synonyms:tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate Edit

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Technology Process of tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 877399-74-1
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1092568-90-5
(3-(5-bromopyrimidin-2-yl)phenyl)methanol

: 1126403-30-2
tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate

Guidance literature:: With potassium phosphate tribasic trihydrate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 80 ℃; for 14h; Inert atmosphere;

Reference yield:

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1126403-30-2
tert-butyl 4-{4-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]-pyrazol-1-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 18 h / 80 °C / Inert atmosphere

2: potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

With potassium phosphate tribasic trihydrate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; toluene;