5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

Base Information

• Chemical Name: 5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione
• CAS No.: 1620323-18-3
• Molecular Formula: C₁₇H₁₂BrN₃O₂
• Molecular Weight: 370.205
• Mol file: 1620323-18-3.mol

Synonyms:5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

Chemical Property of 5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

There total 3 articles about 5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

BARBITURIC ACID (67-52-7,944357-77-1) + 4-bromo-benzaldehyde (1122-91-4) + aniline (62-53-3) → 5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione (1620323-18-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In water; at 90 ℃; for 0.00833333h; Microwave irradiation; Green chemistry;

DOI:10.3184/174751914X13917105358323

Reference yield:

4-bromo-benzaldehyde (1122-91-4) + 6-anilinouracil (7269-15-0) → 5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione (1620323-18-3)

Guidance literature:

In water; glycerol; at 20 ℃; for 0.75h; UV-irradiation; Green chemistry;

DOI:10.1039/c8nj01459k

Reference yield:

aniline (62-53-3) → 5-(4-bromophenyl)-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione (1620323-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; glycerol / 0.25 h / 20 °C / UV-irradiation; Green chemistry

2: water; glycerol / 0.75 h / 20 °C / UV-irradiation; Green chemistry

In water; glycerol;

DOI:10.1039/c8nj01459k

upstream raw materials:

BARBITURIC ACID

4-bromo-benzaldehyde

aniline

6-anilinouracil