ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate

Base Information

• Chemical Name: ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate
• CAS No.: 220951-23-5
• Molecular Formula: C₂₉H₃₂O₃
• Molecular Weight: 428.571
• Mol file: 220951-23-5.mol

Synonyms:ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate

Chemical Property of ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate

There total 1 articles about ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 3'-bromo-4'-hydroxy-biphenyl-4-carboxylate (895542-84-4) + 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylboronic Acid (169126-63-0) → ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate (220951-23-5)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 110 ℃; for 24h;

Reference yield: 100.0%

ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate (220951-23-5) + trifluoromethylsulfonic anhydride (358-23-6) → ethyl 3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4'-trifluoromethanesulfonyloxybiphenyl-4-carboxylate (220949-88-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 3h;

Reference yield: 100.0%

N-(4-bromobutyl)-2,2,2-trifluoro-N-isopropylacetamide + ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate (220951-23-5) → ethyl 4'-{4-[isopropyl-(2,2,2-trifluoro-acetyl)amino]butoxy}-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate

Guidance literature:

ethyl 4'-hydroxy-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.333333h;

N-(4-bromobutyl)-2,2,2-trifluoro-N-isopropylacetamide; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 3h;

upstream raw materials:

ethyl 3'-bromo-4'-hydroxy-biphenyl-4-carboxylate

5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylboronic Acid

Downstream raw materials:

ethyl 4'-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propoxy]-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate

ethyl 4'-(3-bromopropoxy)-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphth-2-yl)biphenyl-4-carboxylate

ethyl 4'-[4-(tert-butyldimethylsilanyloxy)butoxy]-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate

ethyl 4'-[3-(tert-butyldimethylsilanyloxy)propoxy]-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)biphenyl-4-carboxylate