[3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester
• CAS No.: 1026585-76-1
• Molecular Formula: C₂₇H₃₃F₂N₃O₅
• Molecular Weight: 517.573
• Mol file: 1026585-76-1.mol

Synonyms:[3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester

Chemical Property of [3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester

There total 2 articles about [3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-1-(azepan-1-yl)ethanone + 4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxybutanoic acid → [3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester (1026585-76-1)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm000497n

Reference yield:

N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde (59830-60-3,63219-70-5,68474-26-0) → [3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester (1026585-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / aq. K₂CO₃ / tetrahydrofuran; methanol / 20 °C

2: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

With potassium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm000497n

Reference yield:

[3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-hydroxy-propyl]-carbamic acid benzyl ester (1026585-76-1) → 4-amino-2,2-difluoro-3-hydroxy-5-phenyl-pentanoic acid (2-azepan-1-yl-2-oxo-ethyl)-amide; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Guidance literature:

With hydrogenchloride; hydrogen; 10percent Pd/C; In methanol; at 20 ℃; for 15h;

DOI:10.1021/jm000497n

upstream raw materials:

N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

Downstream raw materials:

(1-{[3-(2-azepan-1-yl-2-oxo-ethylcarbamoyl)-1-benzyl-3,3-difluoro-2-oxo-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester