5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide

Base Information

Chemical Name:5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide
CAS No.:98704-76-8
Molecular Formula:C₁₇H₁₈N₂O₃
Molecular Weight:298.342
Hs Code.:

Synonyms:5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide

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Chemical Property of 5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide

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Technology Process of 5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide

There total 5 articles about 5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 98704-75-7
5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine

: 98704-76-8
5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 25 ℃; for 1.5h;
DOI:10.1021/jo00222a011

Reference yield:

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: 98704-76-8
5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 17 h

2: 2.) H₂O, 3.) KMnO₄

3: 74 percent / t-BuOK / tetrahydrofuran / 6 h

4: 94 percent / MCPBA / CHCl₃ / 1.5 h / 25 °C

With potassium permanganate; potassium tert-butylate; water; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo00222a011

Reference yield:

: 56624-12-5,81659-46-3
ethyl (3-pyridyl)imidate dihydrochloride

: 98704-76-8
5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-2-methyl-pyridine 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 17 h

2: 2.) H₂O, 3.) KMnO₄

3: 74 percent / t-BuOK / tetrahydrofuran / 6 h

4: 94 percent / MCPBA / CHCl₃ / 1.5 h / 25 °C

With potassium permanganate; potassium tert-butylate; water; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo00222a011