6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide

Base Information

Chemical Name:6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide
CAS No.:1294002-17-7
Molecular Formula:C₂₃H₂₃F₃N₄O₂
Molecular Weight:444.456
Hs Code.:

Synonyms:6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide

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Chemical Property of 6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide

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Technology Process of 6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide

There total 4 articles about 6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 822-36-6
4-methyl-1H-imidazole

: 1294003-42-1
6-chloro-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide

: 1294002-17-7
6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide

Guidance literature:: 4-methyl-1H-imidazole; 6-chloro-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide; With cesium fluoride; In dimethylsulfoxide-d6; at 140 ℃; for 18h; Inert atmosphere;

With sodium hydrogencarbonate; In dimethylsulfoxide-d6; water;

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1294002-17-7
6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 21.5 h / 20 - 55 °C

2: hydrogen; ammonia / Raney Nickel / methanol / 24 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

4: cesium fluoride / dimethylsulfoxide-d6 / 18 h / 140 °C / Inert atmosphere

With ammonia; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; Raney Nickel; In methanol; dimethylsulfoxide-d6; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1035261-83-6
4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonitrile

: 1294002-17-7
6-(4-methyl-1H-imidazol-1-yl)-N-({4-[3-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-4-yl}methyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; ammonia / Raney Nickel / methanol / 24 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

3: cesium fluoride / dimethylsulfoxide-d6 / 18 h / 140 °C / Inert atmosphere

With ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; Raney Nickel; In methanol; dimethylsulfoxide-d6; N,N-dimethyl-formamide;