methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

Base Information

Chemical Name:methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate
CAS No.:959999-56-5
Molecular Formula:C₂₃H₁₆F₃N₃O₃S
Molecular Weight:471.46
Hs Code.:

Synonyms:methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

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Chemical Property of methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

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Technology Process of methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

There total 1 articles about methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 959999-55-4
methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-hydroxy-2-thiophenecarboxylate

: 959999-54-3
methyl 5-(5-cyano-1H-benzimidazol-1-yl)-3-hydroxy-2-thiophene-carboxylate

: 79756-81-3,127733-44-2,127852-29-3,127852-27-1
(S)-1-(2-trifluoromethylphenyl)ethanol

: 959999-56-5
methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

Guidance literature:: With polystyrene-triphenylphosphine; di-tert-butyl-diazodicarboxylate; In dichloromethane; at 30 ℃; for 12.1667h;

Reference yield:

: 959999-56-5
methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

: methyl 3-((1R)-1-{2-chloro-3-[(1-methylpiperidin-4-yl)oxy]phenyl}ethoxy)-5-(6-cyano-1H-benzimidazol-1-yl)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / 16 h / 70 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

4: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane

With di-tert-butyl-diazodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;

Reference yield:

: 959999-56-5
methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

: 3-{(R)-1-[2-chloro-3-(piperidin-4-yloxy)-phenyl]-ethoxy}-5-(6-cyano-benzoimidazol-1-yl)-thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / 16 h / 70 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

4: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane

5: ammonia / methanol / 24 - 72 h / 80 °C

6: trifluoroacetic acid / dichloromethane

With di-tert-butyl-diazodicarboxylate; tetrabutyl ammonium fluoride; ammonia; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; 2: Mitsunobu reaction;