N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide

Base Information

• Chemical Name: N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide
• CAS No.: 364356-67-2
• Molecular Formula: C₂₉H₄₈N₂O₅
• Molecular Weight: 504.711
• Mol file: 364356-67-2.mol

Synonyms:N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide

Chemical Property of N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide

There total 4 articles about N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-tert-leucinol (112245-13-3) + 2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-propanedioyl dichloride (364356-65-0) → N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide (364356-67-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.583333h;

DOI:10.1002/1521-3773(20010702)40:13<2519::AID-ANIE2519>3.0.CO;2-D

Reference yield:

toluene-4-sulfonic acid 4-(4-vinyl-benzyloxy)-butyl ester (364356-60-5) → N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide (364356-67-2)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 24 h / Heating

2: aq. KOH / 3 h / Heating

3: (COCl)2; DMF / CH₂Cl₂ / 18 h / 20 °C

4: Et₃N / CH₂Cl₂ / 0.58 h / 20 °C

With potassium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/1521-3773(20010702)40:13<2519::AID-ANIE2519>3.0.CO;2-D

Reference yield:

2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonic acid (364356-62-7) → N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonamide (364356-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2; DMF / CH₂Cl₂ / 18 h / 20 °C

2: Et₃N / CH₂Cl₂ / 0.58 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1002/1521-3773(20010702)40:13<2519::AID-ANIE2519>3.0.CO;2-D

upstream raw materials:

(S)-tert-leucinol

2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-propanedioyl dichloride

2-methyl-2-[4-(4-vinyl-benzyloxy)-butyl]-malonic acid

toluene-4-sulfonic acid 4-(4-vinyl-benzyloxy)-butyl ester