trans-4-[(((S)-5-chloro-4-fluoro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

Base Information

• Chemical Name: trans-4-[(((S)-5-chloro-4-fluoro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid
• CAS No.: 1443021-24-6
• Molecular Formula: C₃₁H₃₆ClFN₂O₆
• Molecular Weight: 587.088
• Mol file: 1443021-24-6.mol

Synonyms:trans-4-[(((S)-5-chloro-4-fluoro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

Chemical Property of trans-4-[(((S)-5-chloro-4-fluoro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-[(((S)-5-chloro-4-fluoro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid

There total 2 articles about trans-4-[(((S)-5-chloro-4-fluoro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H38ClFN2O6 → trans-4-[(((S)-5-chloro-4-fluoro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid (1443021-24-6)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 60 ℃; for 3h;

DOI:10.1016/j.bmcl.2016.10.035

Reference yield:

C23H24ClFN2O4 + trans-4-formyl-cyclohexanecarboxylic acid methyl ester (54274-80-5) → trans-4-[(((S)-5-chloro-4-fluoro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexanecarboxylic acid (1443021-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

2: hydrogenchloride; water / 1,4-dioxane / 3 h / 60 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/j.bmcl.2016.10.035

upstream raw materials:

trans-4-formyl-cyclohexanecarboxylic acid methyl ester