(S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester
CAS No.:112127-59-0
Molecular Formula:C₁₉H₂₅NO₈
Molecular Weight:395.409
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester

Chemical Property:

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Technology Process of (S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5672-83-3
Z-L-GluOMe

: 543-27-1
isobutyl chloroformate

: 112127-59-0
(S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at -15 ℃; for 0.25h;
DOI:10.1246/cl.1996.621

Reference yield:

: 112127-59-0
(S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester

: 174488-06-3
methyl (2S)-2-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-methyl-L-γ-glutamyl}amino}-4-(1-methoxycarbonylmethyltetrazol-5-yl)butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.67 h / -20 - 20 °C

2: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 23 h / 11 - 22 °C

3: 0.203 g / DEPC; Et₃N / dimethylformamide / 20 °C

With hydrogen; triethylamine; diethyl dicarbonate; 10percent Pd/C; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p

Reference yield:

: 112127-59-0
(S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester

: (2S)-2-{N-{N-{p-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-L-γ-glutamyl}amino}-4-(1-carboxymethyltetrazol-5-yl)butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1.67 h / -20 - 20 °C

2: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 23 h / 11 - 22 °C

3: 0.203 g / DEPC; Et₃N / dimethylformamide / 20 °C

4: 79 percent / aq. NaOH / methanol / 20 °C

With sodium hydroxide; hydrogen; triethylamine; diethyl dicarbonate; 10percent Pd/C; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p