(5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol

Base Information

• Chemical Name: (5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol
• CAS No.: 930587-83-0
• Molecular Formula: C₃₀H₃₉NO₅
• Molecular Weight: 493.643
• Mol file: 930587-83-0.mol

Synonyms:(5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol

Chemical Property of (5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol

There total 5 articles about (5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(5R,8S,11S,13S,14R)-11-(4-dimethylaminophenyl)-5-hydroxy-13-methyl-1,2,3,4,5,8,11,12,13,14,15,16-dodecahydro-6H-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolan-17-one (930587-82-9) + 1-propynylmagnesium bromide (16466-97-0,13254-27-8) → (5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol (930587-83-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2006.11.062

Reference yield:

(5R,8S,11S,13S,14R)-11-(4-dimethylaminophenyl)-5-hydroxy-13-methyl-1,2,3,4,5,8,11,12,13,14,15,16-dodecahydro-6H-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolan-17-one (930587-82-9) + prop-1-yne (74-99-7) → (5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol (930587-83-0)

Guidance literature:

prop-1-yne; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.25h;

(5R,8S,11S,13S,14R)-11-(4-dimethylaminophenyl)-5-hydroxy-13-methyl-1,2,3,4,5,8,11,12,13,14,15,16-dodecahydro-6H-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolan-17-one; In tetrahydrofuran; at 20 ℃; for 4h; Further stages.;

DOI:10.1016/j.bmcl.2007.02.013

Reference yield:

(8S,13S,14R)-7-oxa-estra-4,9-diene-3,17-dione (924881-78-7) → (5R,8S,11S,13S,14R,17S)-11-(4-dimethylaminophenyl)-13-methyl-17-prop-1-ynyl-1,2,3,4,5,6,8,11,12,13,14,15,16,17-tetradecahydro-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolane-5,17-diol (930587-83-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 82 percent / pyridinium hydrochloride / benzene / 3 h / Heating

2.1: 70 percent / meta-chloroperbenzoic acid; sodium bicarbonate / CH₂Cl₂ / 16 h / -30 °C

3.1: CuCN*2LiCl / tetrahydrofuran / 0 °C

3.2: 88 percent / 1 h / 0 - 20 °C

4.1: 92 percent / tetrahydrofuran / 2 h / 20 °C

With pyridine hydrochloride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1016/j.bmcl.2006.11.062

upstream raw materials:

(5R,8S,11S,13S,14R)-11-(4-dimethylaminophenyl)-5-hydroxy-13-methyl-1,2,3,4,5,8,11,12,13,14,15,16-dodecahydro-6H-7-oxacyclopenta[a]phenanthrene-3-spiro-2'-[1,3]dioxolan-17-one

1-propynylmagnesium bromide

prop-1-yne

(8S,13S,14R)-7-oxa-estra-4,9-diene-3,17-dione