Cyclohexanone, 2-(hydroxymethyl)-3-(methoxymethoxy)-2-methyl-, (2R,3S)- (9CI)

Base Information

Chemical Name:Cyclohexanone, 2-(hydroxymethyl)-3-(methoxymethoxy)-2-methyl-, (2R,3S)- (9CI)
CAS No.:810682-25-8
Molecular Formula:C10H18 O4
Molecular Weight:202.24752
Hs Code.:
Mol file:810682-25-8.mol

Synonyms:Cyclohexanone, 2-(hydroxymethyl)-3-(methoxymethoxy)-2-methyl-, (2R,3S)- (9CI)

Suppliers and Price of Cyclohexanone, 2-(hydroxymethyl)-3-(methoxymethoxy)-2-methyl-, (2R,3S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Cyclohexanone, 2-(hydroxymethyl)-3-(methoxymethoxy)-2-methyl-, (2R,3S)- (9CI)

Chemical Property:

PSA：55.76000
LogP:0.72710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclohexanone, 2-(hydroxymethyl)-3-(methoxymethoxy)-2-methyl-, (2R,3S)- (9CI)

There total 2 articles about Cyclohexanone, 2-(hydroxymethyl)-3-(methoxymethoxy)-2-methyl-, (2R,3S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 810682-51-0
(2R,3S)-2-Benzyloxymethyl-3-methoxymethoxy-2-methyl-cyclohexanone

: 810682-25-8
(2R,3S)-2-Hydroxymethyl-3-methoxymethoxy-2-methyl-cyclohexanone

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 10h;
DOI:10.1016/j.tetlet.2004.09.143

Reference yield:

: 619335-62-5
(2R,3S)-2-Benzyloxymethyl-3-hydroxy-2-methyl-cyclohexanone

: 810682-25-8
(2R,3S)-2-Hydroxymethyl-3-methoxymethoxy-2-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / DIPEA; NaI / CH₂Cl₂ / 48 h / Heating

2: 100 percent / H₂ / Pd/C / methanol / 10 h

With hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.tetlet.2004.09.143

Reference yield:

: 810682-25-8
(2R,3S)-2-Hydroxymethyl-3-methoxymethoxy-2-methyl-cyclohexanone

: Acetic acid (1R,2R,6S)-2-acetoxymethyl-2-hydroxy-6-methoxymethoxy-1-methyl-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / imidazole / CH₂Cl₂ / 1 h

2: 96 percent / NaI / acetone / 10 h / Heating

3: 64 percent / t-BuLi / 0.08 h / -78 °C

4: aq. H₂O₂; KHCO₃; KF / tetrahydrofuran; methanol / 10 h

5: 100 percent / DMAP / CH₂Cl₂

With 1H-imidazole; dmap; potassium fluoride; dihydrogen peroxide; tert.-butyl lithium; potassium hydrogencarbonate; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; acetone; 4: Tamao oxidation;
DOI:10.1016/j.tetlet.2004.09.143