diethyl quinoxaline-2,3-dicarboxylate

Base Information

• Chemical Name: diethyl quinoxaline-2,3-dicarboxylate
• CAS No.: 2379-59-1
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.276
• Mol file: 2379-59-1.mol

Synonyms:diethyl quinoxaline-2,3-dicarboxylate

Chemical Property of diethyl quinoxaline-2,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl quinoxaline-2,3-dicarboxylate

There total 3 articles about diethyl quinoxaline-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

diethyl (Z)-2-(phenylamino)but-2-enedioate → diethyl quinoxaline-2,3-dicarboxylate (2379-59-1) + diethyl 2,2-diazido-3-(phenylimino)succinate

Guidance literature:

With sodium azide; [bis(acetoxy)iodo]benzene; tetrabutylammomium bromide; In 1,2-dichloro-ethane; at 25 ℃;

DOI:10.1002/ejoc.201801081

Reference yield:

aniline (62-53-3) → diethyl quinoxaline-2,3-dicarboxylate (2379-59-1) + diethyl 2,2-diazido-3-(phenylimino)succinate

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium azide / 1,2-dichloro-ethane / 25 °C

2: tetrabutylammomium bromide; sodium azide; [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / 25 °C

With sodium azide; [bis(acetoxy)iodo]benzene; tetrabutylammomium bromide; In 1,2-dichloro-ethane;

DOI:10.1002/ejoc.201801081

Reference yield:

acetylenedicarboxylic acid diethyl ester (762-21-0) → diethyl quinoxaline-2,3-dicarboxylate (2379-59-1) + diethyl 2,2-diazido-3-(phenylimino)succinate

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium azide / 1,2-dichloro-ethane / 25 °C

2: tetrabutylammomium bromide; sodium azide; [bis(acetoxy)iodo]benzene / 1,2-dichloro-ethane / 25 °C

With sodium azide; [bis(acetoxy)iodo]benzene; tetrabutylammomium bromide; In 1,2-dichloro-ethane;

DOI:10.1002/ejoc.201801081

upstream raw materials:

aniline

acetylenedicarboxylic acid diethyl ester

Downstream raw materials:

2,3-dihydropyridazino[4,5-b]quinoxaline-1,4-dione