trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

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Chemical Name:trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide
CAS No.:1607474-44-1
Molecular Formula:C₂₅H₄₀F₃N₅O₂
Molecular Weight:499.62
Hs Code.:

Synonyms:trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

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Chemical Property of trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

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Technology Process of trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

There total 9 articles about trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(4-(2-oxoethyl)cyclohexyl)acetamide

: 1607474-49-6
2-tert-butyl-4-piperazin-1-yl-6-(2-trifluoromethoxyethyl)pyrimidine

: 1607474-43-0
cis-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

: 1607474-44-1
trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Guidance literature:: N-(4-(2-oxoethyl)cyclohexyl)acetamide; 2-tert-butyl-4-piperazin-1-yl-6-(2-trifluoromethoxyethyl)pyrimidine; In methanol; for 0.666667h; pH=5;

With sodium cyanoborohydride; In methanol; at 20 ℃;

Reference yield:

: 1607474-25-8
2-tert-butyl-4-chloro-6-(2-methoxyethyl)pyrimidine

: 1607474-43-0
cis-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

: 1607474-44-1
trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 3 h / Reflux

2.1: boron tribromide / dichloromethane / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

4.2: 2 h / 0 - 20 °C

4.3: 2 h / 0 - 20 °C

5.1: pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hydrogen fluoride / dichloromethane / 0.5 h / -78 °C / Cooling

6.1: palladium on activated charcoal; hydrogen / ethyl acetate / 0.67 h / 775.74 Torr

7.1: methanol / 0.67 h / pH 5

7.2: 20 °C

With pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium on activated charcoal; hydrogen fluoride; hydrogen; boron tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 1607474-23-6
2-tert-butyl-4-(2-methoxyethyl)-6-piperazin-1-ylpyrimidine

: 1607474-43-0
cis-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

: 1607474-44-1
trans-N-[4-(2-{4-[2-tert-butyl-6-(2-trifluoromethoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

3.3: 2 h / 0 - 20 °C

4.1: pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hydrogen fluoride / dichloromethane / 0.5 h / -78 °C / Cooling

5.1: palladium on activated charcoal; hydrogen / ethyl acetate / 0.67 h / 775.74 Torr

6.1: methanol / 0.67 h / pH 5

6.2: 20 °C

With pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium on activated charcoal; hydrogen fluoride; hydrogen; boron tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;