(2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine

Base Information

Chemical Name:(2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine
CAS No.:1234804-87-5
Molecular Formula:C₃₂H₃₉NO₄Si
Molecular Weight:529.751
Hs Code.:

Synonyms:(2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine

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Chemical Property of (2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine

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Technology Process of (2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine

There total 8 articles about (2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1234804-86-4
C₃₃H₄₁NO₄Si

: 1234804-87-5
(2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine

Guidance literature:: With toluene-4-sulfonic acid; In acetone; at 0 ℃; for 0.5h;
DOI:10.3998/ark.5550190.0011.402

Reference yield:

: C₁₅H₁₉NO₅

: 1234804-87-5
(2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 0.5 h / 0 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

4.2: 2 h / 0 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / acetone / 0.5 h / 0 °C

With 1H-imidazole; potassium tert-butylate; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone; toluene; 4.1: |Wittig Olefination;
DOI:10.3998/ark.5550190.0011.402

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1234804-87-5
(2S,5R)-benzyloxycarbonyl-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-(2-oxoethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / 1 h / -78 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / acetone / 0.5 h / 0 °C

With 1H-imidazole; potassium tert-butylate; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; toluene; 3.1: |Wittig Olefination;
DOI:10.3998/ark.5550190.0011.402