methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(pyrimidin-5-yl)phenyl)propanamido)propanoate

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Chemical Name:methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(pyrimidin-5-yl)phenyl)propanamido)propanoate
CAS No.:1240613-32-4
Molecular Formula:C₂₂H₂₇ClN₄O₅
Molecular Weight:462.933
Hs Code.:

Synonyms:methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(pyrimidin-5-yl)phenyl)propanamido)propanoate

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Chemical Property of methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(pyrimidin-5-yl)phenyl)propanamido)propanoate

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Technology Process of methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(pyrimidin-5-yl)phenyl)propanamido)propanoate

There total 1 articles about methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(pyrimidin-5-yl)phenyl)propanamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 4595-59-9
5-bromopyrimidine

: 942070-92-0
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

: 2491-20-5
L-alanine methyl ester hydrochloride

: 1240613-32-4
methyl (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(pyrimidin-5-yl)phenyl)propanamido)propanoate

Guidance literature:: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; With lithium hydroxide; In methanol; water; at 25 ℃; for 3h;

L-alanine methyl ester hydrochloride; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

5-bromopyrimidine; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In dimethyl sulfoxide; at 90 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol1015674