O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol

Base Information

Chemical Name:O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol
CAS No.:288582-53-6
Molecular Formula:C₂₄H₃₆N₂O₃Si
Molecular Weight:428.647
Hs Code.:

Synonyms:O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol

Chemical Property:

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Technology Process of O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol

There total 3 articles about O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 288582-52-5
O-(tert-butyldiphenylsilyl)-(2R)-triphenylmethylamino-3-(tert-butyloxycarbonyl)aminopropanol

: 288582-53-6
O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol

Guidance literature:: With boron trifluoride diethyl etherate; acetic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jo000071g

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 288582-53-6
O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / acetonitrile / 0 - 20 °C

2: 89 percent / DMAP; Et₃N / CH₂Cl₂ / 40 h / 20 °C

3: 88 percent / BF₃*OEt₂; AcOH / CH₂Cl₂ / 2 h / 0 °C

With dmap; boron trifluoride diethyl etherate; acetic acid; triethylamine; In dichloromethane; acetonitrile; 1: Acylation / 2: silylation / 3: detritylation;
DOI:10.1021/jo000071g

Reference yield:

: 288582-51-4
(2R)-triphenylmethylamino-3-(tert-butyloxycarbonyl)aminopropanol

: 288582-53-6
O-(tert-butyldiphenylsilyl)-(2R)-amino-3-(tert-butyloxycarbonyl)aminopropanol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / DMAP; Et₃N / CH₂Cl₂ / 40 h / 20 °C

2: 88 percent / BF₃*OEt₂; AcOH / CH₂Cl₂ / 2 h / 0 °C

With dmap; boron trifluoride diethyl etherate; acetic acid; triethylamine; In dichloromethane; 1: silylation / 2: detritylation;
DOI:10.1021/jo000071g